Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants.

ABSTRACT:

Background/objectives

Delirium is common in older adults, especially following hospitalization. Because low vitamin D levels may be associated with increased delirium risk, we aimed to determine the prognostic value of blood vitamin D levels, extending our previous genetic analyses of this relationship.

Design

Prospective cohort analysis.

Setting

Community-based cohort study of adults from 22 cities across the United Kingdom (the UK Biobank).

Participants

Adults aged 60 and older by the end of follow-up in the linked hospital inpatient admissions data, up to 14 years after baseline (n = 351,320).

Measurements

At baseline, serum vitamin D (25-OH-D) levels were measured. We used time-to-event models to estimate hazard ratios (HRs) and 95% confidence interv

SUBMITTER: Pilling LC 

PROVIDER: S-EPMC7902418 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature