Vitamin A and D Absorption in Adults with Metabolic Syndrome versus Healthy Controls: A Pilot Study Utilizing Targeted and Untargeted LC-MS Lipidomics.

ABSTRACT:

Scope

Persons with metabolic syndrome (MetS) absorb less vitamin E than healthy controls. It is hypothesized that absorption of fat-soluble vitamins (FSV) A and D₂ would also decrease with MetS status and that trends would be reflected in lipidomic responses between groups.

Methods and results

Following soymilk consumption (501 IU vitamin A, 119 IU vitamin D₂ ), the triglyceride-rich lipoprotein fractions (TRL) from MetS and healthy subjects (n = 10 age- and gender-matched subjects/group) are assessed using LC-MS/MS. Absorption is calculated using area under the time-concentration curves (AUC) from samples collected at 0, 3, and 6 h post-ingestion. MetS subjects have ≈6.4-fold higher median vitamin A AUC (retinyl palmitate) versus healthy controls (P =

SUBMITTER: Chatelaine H 

PROVIDER: S-EPMC7902427 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature