Rational Design of High-Relaxivity Eu^II -Based Contrast Agents for Magnetic Resonance Imaging of Low-Oxygen Environments.

ABSTRACT: Metal-based contrast agents for magnetic resonance imaging present a promising avenue to image hypoxia. Eu^II -based contrast agents have a unique biologically relevant redox couple, Eu^II/III , that distinguishes this metal for use in hypoxia imaging. To that end, we investigated a strategy to enhance the contrast-enhancing capabilities of Eu^II -based cryptates in magnetic resonance imaging by controlling the rotational dynamics. Two dimetallic, Eu^II -containing cryptates were synthesized to test the efficacy of rigid versus flexible coupling strategies. A flexible strategy to dimerization led to a modest (114 %) increase in contrast enhancement per Eu ion (60 MHz, 298 K), but a rigid linking strategy led to an excellent (186 %) increase in contra

SUBMITTER: Bailey MD 

PROVIDER: S-EPMC7902434 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature