Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake.

ABSTRACT:

Objective

Hyperglycemia is a common comorbidity for ischemic stroke and is associated with worsened neurological outcomes. Platelets are central mediators of ischemic stroke and hyperglycemia mediates platelet hyperactivity. In this study, we investigated the contribution of platelet glucose metabolism to ischemic stroke.

Methods

Mice lacking both Glut1 and Glut3 specifically in platelets (DKO) and their littermate controls (WT) were subjected to 1-hour transient middle cerebral artery occlusion under normoglycemic and streptozotocin-induced hyperglycemic conditions after which stroke outcomes, platelet activation, and platelet-neutrophil aggregate (PNA) formation were examined.

Results

Under normoglycemic conditions, DKO mice were protected from ischemic stroke with

SUBMITTER: Denorme F 

PROVIDER: S-EPMC7902465 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature