All-Polymer Printed Low-Cost Regenerative Nerve Cuff Electrodes.

ABSTRACT: Neural regeneration after lesions is still limited by several factors and new technologies are developed to address this issue. Here, we present and test in animal models a new regenerative nerve cuff electrode (RnCE). It is based on a novel low-cost fabrication strategy, called "Print and Shrink", which combines the inkjet printing of a conducting polymer with a heat-shrinkable polymer substrate for the development of a bioelectronic interface. This method allows to produce miniaturized regenerative cuff electrodes without the use of cleanroom facilities and vacuum based deposition methods, thus highly reducing the production costs. To fully proof the electrodes performance in vivo we assessed functional recovery and adequacy to support axonal regeneration after section of rat scia

SUBMITTER: Ferrari LM 

PROVIDER: S-EPMC7902501 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature