Indirect effect of oral azithromycin on the gut resistome of untreated children: a randomized controlled trial.

ABSTRACT:

Background

Antibiotic use by one individual may affect selection for antimicrobial resistance in close contacts. Here we evaluated whether oral antibiotic treatment of one child within a household affected the gut resistome of an untreated cohabiting child.

Methods

Households with at least two children <5 y of age were randomized in a 1:1 fashion to a 5d course of azithromycin or placebo. To evaluate indirect effects of azithromycin treatment on the gut resistome, we randomly assigned one child in the house to azithromycin and one to placebo. In placebo households, each child received placebo. We performed DNA sequencing of rectal swabs collected 5 d after the last antibiotic dose. We estimated risk ratios for the presence of genetic resistance determinants at the class leve

SUBMITTER: Oldenburg CE 

PROVIDER: S-EPMC7902679 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature