Predominance of Non-carbapenemase Producing Carbapenem-Resistant Enterobacterales in South Texas.

ABSTRACT:

Background

Carbapenem-resistant Enterobacterales (CRE) pose a significant global public health threat. Resistance among CRE is particularly complex, owing to numerous possible resistance mechanisms and broad definitions. We aimed to characterize the clinical and molecular profiles of CRE in the South Texas region.

Materials and methods

We compared the clinical, genotypic, and phenotypic profiles of carbapenemase producing Enterobacterales (CPE) with those of non-carbapenemase producers (NCPE) isolated from South Texas, United States between 2011 and 2019. Molecular characteristics and resistance mechanisms were analyzed using whole-genome sequences.

Results

The majority (59%) of the CRE isolates were NCPE while 41% of isolates harbored carbapenemases, predmonantly

SUBMITTER: Black CA 

PROVIDER: S-EPMC7902696 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature