Re-Clustering and Profiling of Digestive System Tumors According to Microenvironment Components.

ABSTRACT:

Background

Immunotherapy has become the most promising therapy in digestive system tumors besides conventional chemotherapy and radiotherapy. But only a few patients can benefit from different types of immunotherapies, such as immune checkpoint blockade (ICB). To identify these ICB-susceptible patients, methods are urgently needed to screen and profile subgroups of patients with different responsiveness to ICB.

Methods

This study carried out analysis on patients with digestive system tumors that were obtained from Cancer Genome Atlas (TCGA) cohorts. The analyses were mainly performed using GraphPad Prism 7 and R language.

Results

We have quantified the microenvironmental components of eight digestive system tumor patients in TCGA cohorts and evaluated their clinical v

SUBMITTER: Wang Y 

PROVIDER: S-EPMC7902780 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature