Soluble syndecan-1 and glycosaminoglycans in preeclamptic and normotensive pregnancies.

ABSTRACT: Preeclampsia, an important cause of maternal and fetal morbidity and mortality, is associated with increased sFLT1 levels and with structural and functional damage to the glycocalyx contributing to endothelial dysfunction. We investigated glycocalyx components in relation to preeclampsia in human samples. While soluble syndecan-1 and heparan sulphate were similar in plasma of preeclamptic and normotensive pregnant women, dermatan sulphate was increased and keratan sulphate decreased in preeclamptic women. Dermatan sulphate was correlated with soluble syndecan-1, and inversely correlated with blood pressure and activated partial thromboplastin time. To determine if syndecan-1 was a prerequisite for the sFlt1 induced increase in blood pressure in mice we studied the effect of sFlt1 on blood

SUBMITTER: Hassani Lahsinoui H 

PROVIDER: S-EPMC7902809 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature