Predicting Individual Pain Thresholds From Morphological Connectivity Using Structural MRI: A Multivariate Analysis Study.

ABSTRACT: Pain sensitivity is highly variable among individuals, and it is clinically important to predict an individual's pain sensitivity for individualized diagnosis and management of pain. Literature has shown that pain sensitivity is associated with regional structural features of the brain, but it remains unclear whether pain sensitivity is also related to structural brain connectivity. In the present study, we investigated the relationship between pain thresholds and morphological connectivity (MC) inferred from structural MRI based on data of 221 healthy participants. We found that MC was highly predictive of an individual's pain thresholds and, importantly, it had a better prediction performance than regional structural features. We also identified a number of most predictive MC features an

SUBMITTER: Zou R 

PROVIDER: S-EPMC7902866 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature