PTPN21/Pez Is a Novel and Evolutionarily Conserved Key Regulator of Inflammation In Vivo.

ABSTRACT: Drosophila provides a powerful model in which to study inflammation in vivo, and previous studies have revealed many of the key signaling events critical for recruitment of immune cells to tissue damage. In the fly, wounding stimulates the rapid production of hydrogen peroxide (H₂O₂).^1,2 This then acts as an activation signal by triggering a signaling pathway within responding macrophages by directly activating the Src family kinase (SFK) Src42A,³ which in turn phosphorylates the damage receptor Draper. Activated Draper then guides macrophages to the wound through the detection of an as-yet unidentified chemoattractant.^3-5 Similar H₂O₂-activated signaling pathways are also critical for leukoc

SUBMITTER: Campbell JS 

PROVIDER: S-EPMC7902905 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature