Neurofascin Is a Novel Component of Rod Photoreceptor Synapses in the Outer Retina.

ABSTRACT: Neural circuit formation is an intricate and complex process where multiple neuron types must come together to form synaptic connections at a precise location and time. How this process is orchestrated during development remains poorly understood. Cell adhesion molecules are known to play a pivotal role in assembling neural circuits. They serve as recognition molecules between corresponding synaptic partners. In this study, we identified a new player in assembling neural circuits in the outer retina, the L1-family cell adhesion molecule Neurofascin (Nfasc). Our data reveals Nfasc is expressed in the synaptic layer where photoreceptors make synaptic connections to their respective partners. A closer examination of Nfasc expression shows high levels of expression in rod bipolars but not in c

SUBMITTER: Pourhoseini S 

PROVIDER: S-EPMC7902911 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature