Association of <i>SNCA</i> Parkinson's Disease Risk Polymorphisms With Disease Progression in Newly Diagnosed Patients.

ABSTRACT: Objectives: To evaluate the impact of SNCA polymorphisms originally identified as risk factors for Parkinson's disease (PD) on the clinical presentation and progression of the disease in a large cohort of population-based patients with incident PD. Methods: Four hundred thirty-three patients and 417 controls from three longitudinal cohorts were included in the study. Disease progression was recorded annually for up to 9 years using the Unified Parkinson's Disease Rating Scale (UPDRS) or Mini-Mental State Examination. Genotypes for five variants within the SNCA locus (rs2870004, rs356182, rs5019538, rs356219, and rs763443) were determined. We studied the association between each variant and disease progression using linear mixed-effects regression models. Resu

SUBMITTER: Szwedo AA 

PROVIDER: S-EPMC7902914 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature