M⁶A RNA Methylation Regulators Act as Potential Prognostic Biomarkers in Lung Adenocarcinoma.

ABSTRACT: N⁶-methyladenosine [m(6)A/m⁶A] methylation is one of the most common RNA modifications in eukaryotic cell mRNA and plays an important regulatory role in mRNA metabolism, splicing, translocation, stability, and translation. Previous studies have demonstrated that the m⁶A modification is highly associated with tumor cell proliferation, migration, and invasion. In the present study, five m⁶A regulatory factors have been revealed, namely heterogeneous nuclear ribonucleoprotein A2/B1(HNRNPA2B1), heterogeneous nuclear ribonucleoprotein C (HNRNPC), Vir like m⁶A methyltransferase associated protein (KIAA1429/VIRMA), RNA binding motif protein 15 (RBM15) and methyltransferase like 3 (METTL3), which are closely related to the overall survival (OS

SUBMITTER: Wang H 

PROVIDER: S-EPMC7902930 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature