Utility of Plasma Neurofilament Light in the 1Florida Alzheimer's Disease Research Center (ADRC).

ABSTRACT:

Background

Plasma NfL (pNfL) levels are elevated in many neurological disorders. However, the utility of pNfL in a clinical setting has not been established.

Objective

In a cohort of diverse older participants, we examined: 1) the association of pNfL to age, sex, Hispanic ethnicity, diagnosis, and structural and amyloid imaging biomarkers; and 2) its association to baseline and longitudinal cognitive and functional performance.

Methods

309 subjects were classified at baseline as cognitively normal (CN) or with cognitive impairment. Most subjects had structural MRI and amyloid PET scans. The most frequent etiological diagnosis was Alzheimer's disease (AD), but other neurological and neuropsychiatric disorders were also represented. We assessed the relationship of pNfL

SUBMITTER: Barker W 

PROVIDER: S-EPMC7902971 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature