TFEB deficiency attenuates mitochondrial degradation upon brown adipose tissue whitening at thermoneutrality.

ABSTRACT:

Objective

Brown adipose tissue (BAT) thermogenesis offers the potential to improve metabolic health in mice and humans. However, humans predominantly live under thermoneutral conditions, leading to BAT whitening, a reduction in BAT mitochondrial content and metabolic activity. Recent studies have established mitophagy as a major driver of mitochondrial degradation in the whitening of thermogenic brite/beige adipocytes, yet the pathways mediating mitochondrial breakdown in whitening of classical BAT remain largely elusive. The transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy belonging to the MiT family of transcription factors, is the only member of this family that is upregulated during whitening, pointing toward a role of TFEB in whitening-a

SUBMITTER: Sass F 

PROVIDER: S-EPMC7903014 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature