Borrelidin from Saltern-Derived Halophilic Nocardiopsis sp. Dissociates Amyloid-β and Tau Fibrils.

ABSTRACT:

Background

Alzheimer's disease (AD) is characterized by the aggregation of two pathological proteins, amyloid-β (Aβ) and tau, leading to neuronal and cognitive dysfunction. Clearance of either Aβ or tau aggregates by immunotherapy has become a potential therapy, as these aggregates are found in the brain ahead of the symptom onset. Given that Aβ and tau independently and cooperatively play critical roles in AD development, AD treatments might require therapeutic approaches to eliminate both aggregates together.

Objective

We aimed to discover a chemical drug candidate from natural sources for direct dissociation of both insoluble Aβ and tau aggregates through in vitro assessments.

Methods

We isolated four borrelidin chemicals from a saltern-derived halophilic ac

SUBMITTER: Shin J 

PROVIDER: S-EPMC7903018 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature