Test accuracy of faecal calprotectin for inflammatory bowel disease in UK primary care: a retrospective cohort study of the IMRD-UK data.

ABSTRACT:

Objective

To estimate the test accuracy of faecal calprotectin (FC) for inflammatory bowel disease (IBD) in the primary care setting using routine electronic health records.

Design

Retrospective cohort test accuracy study.

Setting

UK primary care.

Participants

5970 patients (≥18 years) without a previous IBD diagnosis and with a first FC test between 1 January 2006 and 31 December 2016. We excluded multiple tests and tests without numeric results in units of µg/g.

Intervention

FC testing for the diagnosis of IBD. Disease status was confirmed by a recorded diagnostic code and/or a drug code of an IBD-specific medication at three time points after the FC test date.

Main outcome measures

Sensitivity, specificity, and positive and negative predictive

SUBMITTER: Freeman K 

PROVIDER: S-EPMC7903095 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature