Cause of preterm birth and late-onset sepsis in very preterm infants: the EPIPAGE-2 cohort study.

ABSTRACT:

Background

The pathogenesis of late-onset sepsis (LOS) in preterm infants is poorly understood and knowledge about risk factors, especially prenatal risk factors, is limited. This study aimed to assess the association between the cause of preterm birth and LOS in very preterm infants.

Methods

2052 very preterm singletons from a national population-based cohort study alive at 72 h of life were included. Survival without LOS was compared by cause of preterm birth using survival analysis and Cox regression models.

Results

437 (20.1%) had at least one episode of LOS. The frequency of LOS varied by cause of preterm birth: 17.1% for infants born after preterm labor, 17.9% after preterm premature rupture of membranes, 20.3% after a placental abruption, 20.3% after isolated h

SUBMITTER: Letouzey M 

PROVIDER: S-EPMC7903216 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature