Hydrogen Sulfide Protects Against Uremic Accelerated Atherosclerosis via nPKCδ/Akt Signal Pathway.

ABSTRACT: Background: Cardiovascular disease is the most common complication and leading cause of death in maintenance hemodialysis patients. Previous studies have found that disorders of cystathionine-gamma-lyase/hydrogen sulfide (CSE/H₂S) system in maintenance hemodialysis patients are correlated with the risk of cardiovascular disease. Although the role of CSE/H₂S system in UAAS has been preliminarily explored, the molecular mechanism of CSE/H₂S is still not systematically elaborated, and the molecular mechanism of nPKCδ and its related signaling pathway in UAAS is still not thoroughly studied. Methods: Forty chronic kidney disease (CHD) patients were studied and the activation of nPKCδ in peripheral blood mononuclear cells (PBMCs) were detected. Apo

SUBMITTER: Lu X 

PROVIDER: S-EPMC7903246 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature