Mismatch Repair Universal Screening of Endometrial Cancers (MUSE) in a Canadian Cohort.

ABSTRACT:

Background

Approximately 2-6% of endometrial cancers (ECs) are due to Lynch Syndrome (LS), a cancer predisposition syndrome caused by germline pathogenic variants (PVs) affecting the DNA mismatch repair (MMR) pathway. Increasingly, universal tissue-based screening of ECs has been proposed as an efficient and cost-effective way to identify families with LS, though few studies have been published on Canadian cohorts. The purpose of this study was to evaluate the feasibility and overall performance of a universal immunohistochemistry (IHC) screening program for women with EC within a single Canadian university hospital centre.

Methods and results

From 1 October 2015 to 31 December 2017, all newly diagnosed ECs (n = 261) at our centre were screened for MMR protein deficiency by

SUBMITTER: Lawrence J 

PROVIDER: S-EPMC7903281 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature