What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review.

ABSTRACT: Awareness of one's own cognitive processes (metacognition) or of one's own illness or deficits (anosognosia) can be impaired in people with Alzheimer's disease (AD). The neural correlates of anosognosia within AD remain inconclusive. Understanding anosognosia is of importance because of its impact on carer burden and increased institutionalization. A systematic review of structural and functional neuroimaging studies was conducted to identify specific brain regions associated with anosognosia within AD. Thirty-two studies were included in the systematic review. Reduced gray matter density, cerebral blood flow, and hypometabolism in 8 key regions were significantly associated with increased anosognosia scores in people with AD. The most frequently associated regions were the inferior fronta

SUBMITTER: Hallam B 

PROVIDER: S-EPMC7903321 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature