Ontology highlight
ABSTRACT:
SUBMITTER: Tremble KC
PROVIDER: S-EPMC7903329 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
iScience 20210206 3
Induced pluripotency provides a tool to explore mechanisms underlying establishment, maintenance, and differentiation of naive pluripotent stem cells (nPSCs). Here, we report that self-renewal of nPSCs requires minimal Sox2 expression (Sox2-low). Sox2-low nPSCs do not show impaired neuroectoderm specification and differentiate efficiently <i>in vitro</i> into all embryonic germ lineages. Strikingly, upon the removal of self-renewing cues Sox2-low nPSCs differentiate into both embryonic and extra ...[more]