Risk levels of herb-induced liver injury in Korea: from a meta-analysis.

ABSTRACT:

Background

As the use of herbal medicines increased worldwide, there has been concern about the risk of herb-induced liver injury (HILI). Many clinical studies have assessed the risk of HILI in Korea.

Methods

Therefore, we conducted a meta-analysis of the incidence of HILI in Korea, by analyzing nine clinical studies. These involved 8625 participants (3274 males; 5351 females), including 436 outpatients (three studies) and 8189 inpatients (six studies).

Results

As a result, the overall incidence of HILI in Korea was 0.49% (95% CI 0.33-0.74%), and it was 0.57% in males and 0.30% in females. We found a similar incidence of HILI in prospective (0.51%) and retrospective (0.50%) studies. The incidence of HILI was higher in inpatients (0.62%) than outpatients (0.03%).

Co

SUBMITTER: Lee NH 

PROVIDER: S-EPMC7903345 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature