Statin treatment and muscle symptoms: series of randomised, placebo controlled n-of-1 trials.

ABSTRACT:

Objective

To establish the effect of statins on muscle symptoms in people who had previously reported muscle symptoms when taking statins.

Design

Series of randomised, placebo controlled n-of-1 trials.

Setting

Primary care across 50 sites in the United Kingdom, December 2016 to April 2018.

Participants

200 participants who had recently stopped or were considering stopping treatment with statins because of muscle symptoms.

Interventions

Participants were randomised to a sequence of six double blinded treatment periods (two months each) of atorvastatin 20 mg daily or placebo.

Main outcome measures

At the end of each treatment period, participants rated their muscle symptoms on a visual analogue scale (0-10). The primary analysis compared symptom sco

SUBMITTER: Herrett E 

PROVIDER: S-EPMC7903384 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature