Chimeric antigen receptor-natural killer cells: Novel insight into immunotherapy for solid tumors (Review).

ABSTRACT: The chimeric antigen receptor (CAR) is an artificially modified fusion protein consisting of an extracellular antigen-binding domain, transmembrane domain and intracellular signalling domain. CAR-T therapy has demonstrated remarkable clinical efficacy in hematological malignancies. However, cytokine release syndrome and other side effects have hindered its application in solid tumors. CAR-natural killer (NK) cells have attracted broad attention due to their safety in clinical applications, their mechanism in recognising cancer cells and the abundance of its clinical specimens. Preclinical and clinical trials of human primary NK cells and NK-92 cell lines demonstrated that CAR-NK cells are able to fight haematological malignancies and solid tumors. However, the implication of CAR-NK cell th

SUBMITTER: Peng X 

PROVIDER: S-EPMC7903426 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature