Integrated Network and Gene Ontology Analysis Identifies Key Genes and Pathways for Coronary Artery Diseases.

ABSTRACT:

Background

The prevalence of Coronary Artery Disease (CAD) in developing countries is on the rise, owing to rapidly changing lifestyle. Therefore, it is imperative that the underlying genetic and molecular mechanisms be understood to develop specific treatment strategies. Comprehensive disease network and Gene Ontology (GO) studies aid in prioritizing potential candidate genes for CAD and also give insights into gene function by establishing gene and disease pathway relationships.

Methods

In the present study, CAD-associated genes were collated from different data sources and protein-protein interaction network was constructed using STRING. Highly interconnected network clusters were inferred and GO analysis was performed.

Results

Interrelation between genes and pathw

SUBMITTER: Prakash T 

PROVIDER: S-EPMC7903433 | biostudies-literature | 2021 Jan-Mar

REPOSITORIES: biostudies-literature