Structure of nevanimibe-bound tetrameric human ACAT1.

ABSTRACT: Cholesterol is an essential component of mammalian cell membranes, constituting up to 50% of plasma membrane lipids. By contrast, it accounts for only 5% of lipids in the endoplasmic reticulum (ER)¹. The ER enzyme sterol O-acyltransferase 1 (also named acyl-coenzyme A:cholesterol acyltransferase, ACAT1) transfers a long-chain fatty acid to cholesterol to form cholesteryl esters that coalesce into cytosolic lipid droplets. Under conditions of cholesterol overload, ACAT1 maintains the low cholesterol concentration of the ER and thereby has an essential role in cholesterol homeostasis^2,3. ACAT1 has also been implicated in Alzheimer's disease⁴, atherosclerosis⁵ and cancers⁶. Here we report a cryo-electron microscopy structure of human ACAT

SUBMITTER: Long T 

PROVIDER: S-EPMC7903523 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature