Activin a suppresses peripheral CD8⁺ T lymphocyte activity in acute-phase Kawasaki disease.

ABSTRACT:

Background

Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old. Previous studies have found that the over-activation of lymphocytes is an important mechanism of Kawasaki disease. Activin A, also known as immunosuppressive factor P, is a multifunctional growth and transforming factor. However, whether activin A is involved in the regulation of peripheral lymphocytes activity in Kawasaki disease is unclear. Thus, we aimed to investigate the effect of activin A on the activity of peripheral lymphocytes in acute-phase Kawasaki disease.

Methods

Seven patients with Kawasaki disease and seven healthy controls were studied. Peripheral blood lymphocytes were isolated by Ficoll densi

SUBMITTER: Wu Q 

PROVIDER: S-EPMC7903692 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature