Beta-blocker therapy in patients with COPD: a systematic literature review and meta-analysis with multiple treatment comparison.

ABSTRACT:

Background

Beta-blockers are associated with reduced mortality in patients with cardiovascular disease but are often under prescribed in those with concomitant COPD, due to concerns regarding respiratory side-effects. We investigated the effects of beta-blockers on outcomes in patients with COPD and explored within-class differences between different agents.

Methods

We searched the Cochrane Central Register of Controlled Trials, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL) and Medline for observational studies and randomized controlled trials (RCTs) investigating the effects of beta-blocker exposure versus no exposure or placebo, in patients with COPD, with and without cardiovascular indications. A meta-analysis was performed to assess the associ

SUBMITTER: Gulea C 

PROVIDER: S-EPMC7903749 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature