Discovery of novel community-relevant small proteins in a simplified human intestinal microbiome.

ABSTRACT:

Background

The intestinal microbiota plays a crucial role in protecting the host from pathogenic microbes, modulating immunity and regulating metabolic processes. We studied the simplified human intestinal microbiota (SIHUMIx) consisting of eight bacterial species with a particular focus on the discovery of novel small proteins with less than 100 amino acids (= sProteins), some of which may contribute to shape the simplified human intestinal microbiota. Although sProteins carry out a wide range of important functions, they are still often missed in genome annotations, and little is known about their structure and function in individual microbes and especially in microbial communities.

Results

We created a multi-species integrated proteogenomics search database (iPtgxDB) to e

SUBMITTER: Petruschke H 

PROVIDER: S-EPMC7903761 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature