Trimers Conjugated to Fibrin Hydrogels Promote Salivary Gland Function.

ABSTRACT: New strategies for tissue engineering have great potential for restoring and revitalizing impaired tissues and organs, including the use of smart hydrogels that can be modified to enhance organization and functionality of the salivary glands. For instance, monomers of laminin-111 peptides chemically conjugated to fibrin hydrogel (L_1pM-FH) promote cell cluster formation in vitro and salivary gland regeneration in vivo when compared with fibrin hydrogel (FH) alone; however, L_1pM-FH produce only weak expression of acinar differentiation markers in vivo (e.g., aquaporin-5 and transmembrane protein 16). Since previous studies demonstrated that a greater impact can be achieved when trimeric forms were used as compared with monomeric or dimeric forms, we investigated the ext

SUBMITTER: Dos Santos HT 

PROVIDER: S-EPMC7903845 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature