Socioeconomic Status Mediates Racial Differences Seen Using the AT(N) Framework.

ABSTRACT:

Objectives

African Americans are at greater risk for developing Alzheimer's disease (AD) dementia than non-Hispanic whites. In addition to biological considerations (eg, genetic influences and comorbid disorders), social and environmental factors may increase the risk of AD dementia. This paper (1) assesses neuroimaging biomarkers of amyloid (A), tau (T), and neurodegeneration (N) for potential racial differences and (2) considers mediating effects of socioeconomic status (SES) and measures of small vessel and cardiovascular disease on observed race differences.

Methods

Imaging measures of AT(N) (amyloid and tau positron emission tomography [PET]) structural magnetic resonance imaging (MRI), and resting state functional connectivity (rs-fc) were collected from African Americ

SUBMITTER: Meeker KL 

PROVIDER: S-EPMC7903892 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature