Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis.

ABSTRACT:

Background and purpose

Assessing whether modifiable risk factors are causally associated with stroke risk is important in planning public health measures, but determining causality can be difficult in epidemiological data. We evaluated whether modifiable lifestyle factors including educational attainment, smoking, and body mass index are causal risk factors for ischemic stroke and its subtypes and hemorrhagic stroke.

Methods

We performed 2-sample and multivariable Mendelian randomization to assess the causal effect of 12 lifestyle factors on risk of stroke and whether these effects are independent.

Results

Genetically predicted years of education was inversely associated with ischemic, large artery, and small vessel stroke, and intracerebral hemorrhage. Genetically pr

SUBMITTER: Harshfield EL 

PROVIDER: S-EPMC7903981 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature