VDAC1 Conversely Correlates with Cytc Expression and Predicts Poor Prognosis in Human Breast Cancer Patients.

ABSTRACT:

Aim

The main objective of this article was to evaluate the association of voltage-dependent anion channel 1 (VDAC1) with Cytochrome C (Cytc) expression, various clinicopathological features, and prognosis in breast cancer (BC) patients. Meanwhile, the correlation of Cytc expression with various clinical features and 5-year disease-free survival (5-DFS) of BC was also investigated.

Methods

In vivo, expression of VDAC1 and Cytc was examined in 219 BC tissues and 100 benign breast lesions by immunohistochemical (IHC) analysis. In vitro, MTT and wound healing migration assay were performed to detect the effect of VDAC1 on BC cells.

Results

Expression of VDAC1 is conversely associated with Cytc in BC (P = 0.011), especially in triple-negative breast ca

SUBMITTER: Chen F 

PROVIDER: S-EPMC7904344 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature