MicroRNAs Related to Cognitive Impairment After Hearing Loss.

ABSTRACT:

Objectives

Our research group has previously demonstrated that hearing loss might be a risk factor for synaptic loss within the hippocampus and impairment of cognition using an animal model of Alzheimer disease. In this study, after inducing hearing loss in a rat model of Alzheimer disease, the associations of various microRNAs (miRNAs) with cognitive impairment were investigated.

Methods

Rats were divided randomly into two experimental groups: the control group, which underwent sham surgery and subthreshold amyloid-β infusion and the deaf group, which underwent bilateral cochlear ablation and subthreshold amyloid-β infusion. All rats completed several cognitive function assessments 11 weeks after surgery, including the object-in-place task (OPT), the novel object recognitio

SUBMITTER: Mun SK 

PROVIDER: S-EPMC7904421 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature