An Initial Empirical Operationalization of the Earliest Stages of the Alzheimer's Continuum.

ABSTRACT:

Purpose

The Alzheimer's Continuum (AC) includes 2 preclinical stages defined by subjective cognitive complaints, transitional cognitive declines, and neurobehavioral symptoms. Operationalization of these stages is necessary for them to be applied in research.

Methods

Cognitively normal individuals with known amyloid biomarker status were selected from the National Alzheimer's Coordinating Center Uniform Data Set. Participants and their caregivers provided information on subjective cognitive complaints, neurobehavioral features, and objective cognitive functioning.

Patients

The sample included 101 amyloid positive (A+) and 447 amyloid negative (A-) individuals.

Results

Rates of subjective cognitive complaints (A+: 34.90%, A-: 29.90%) and neurobehavioral symptoms

SUBMITTER: Kiselica AM 

PROVIDER: S-EPMC7904575 | biostudies-literature | 2021 Jan-Mar 01

REPOSITORIES: biostudies-literature