Developmental effects in physiological stress in early adolescents with and without autism spectrum disorder.

ABSTRACT:

Introduction

Humans place high value on how they are socially evaluated by others. The Trier Social Stress Test (TSST) is a well-established measure of social evaluative threat that promotes activation of the hypothalamic pituitary adrenal (HPA) axis and release of cortisol. Higher cortisol responses in typically developing (TD) adolescents are influenced by age and pubertal development especially in later stages. Children with ASD have been shown to exhibit blunted cortisol in response to the TSST although adults with ASD show a more prototypical response. The current study examined physiological stress in early adolescents with ASD and TD. It was hypothesized that TD youth would show elevated cortisol in response to the TSST influenced by age and pubertal stage. In contrast, yout

SUBMITTER: Corbett BA 

PROVIDER: S-EPMC7904615 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature