Association Between Midlife Obesity and Kidney Function Trajectories: The Atherosclerosis Risk in Communities (ARIC) Study.

ABSTRACT:

Rationale & objective

Obesity has been related to risk for chronic kidney disease. However, the associations of different measures of midlife obesity with long-term kidney function trajectories and whether they differ by sex and race are unknown.

Study design

Observational study.

Setting & participants

13,496 participants from the Atherosclerosis Risk in Communities (ARIC) Study.

Predictors

Midlife obesity status as measured by body mass index (BMI), waist-to-hip ratio, and predicted percent fat at baseline.

Outcomes

Estimated glomerular filtration rate (eGFR) calculated using serum creatinine level measured at 5 study visits, and incident kidney failure with replacement therapy (KFRT).

Analytical approach

Mixed models with random intercepts and r

SUBMITTER: Yu Z 

PROVIDER: S-EPMC7904650 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature