Mitochondrial fission factor (Mff) is required for organization of the mitochondrial sheath in spermatids.

ABSTRACT:

Background

Mitochondrial fission counterbalances fusion to maintain organelle morphology, but its role during development remains poorly characterized. Mammalian spermatogenesis is a complex developmental process involving several drastic changes to mitochondrial shape and organization. Mitochondria are generally small and spherical in spermatogonia, elongate during meiosis, and fragment in haploid round spermatids. Near the end of spermatid maturation, small mitochondrial spheres line the axoneme, elongate, and tightly wrap around the midpiece to form the mitochondrial sheath, which is critical for fueling flagellar movements. It remains unclear how these changes in mitochondrial morphology are regulated and how they affect sperm development.

Methods

We used genetic ablatio

SUBMITTER: Varuzhanyan G 

PROVIDER: S-EPMC7904653 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature