Parental decision making regarding consent to randomization on Children's Oncology Group AALL0932.

ABSTRACT:

Background

Within pediatric oncology, parental decision making regarding participation in clinical trials that aim to reduce therapy to mitigate side effects is not well studied. The recently completed Children's Oncology Group trial for standard-risk acute lymphoblastic leukemia (AALL0932) included a reduction in maintenance therapy, and required consent for randomization immediately prior to starting maintenance. At our institution, 40% of children enrolled on AALL0932 were withdrawn from protocol therapy prior to randomization due to parental choice. This study sought to identify factors that impacted parental decision making regarding randomization on AALL0932.

Procedure

Parents of children enrolled on AALL0932 at our institution were eligible if their child met criteria

SUBMITTER: Parker K 

PROVIDER: S-EPMC7904659 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature