The ZIP6/ZIP10 heteromer is essential for the zinc-mediated trigger of mitosis.

ABSTRACT: Zinc has been known to be essential for cell division for over 40 years but the molecular pathways involved remain elusive. Cellular zinc import across biological membranes necessitates the help of zinc transporters such as the SLC39A family of ZIP transporters. We have discovered a molecular process that explains why zinc is required for cell division, involving two highly regulated zinc transporters, as a heteromer of ZIP6 and ZIP10, providing the means of cellular zinc entry at a specific time of the cell cycle that initiates a pathway resulting in the onset of mitosis. Crucially, when the zinc influx across this heteromer is blocked by ZIP6 or ZIP10 specific antibodies, there is no evidence of mitosis, confirming the requirement for zinc influx as a trigger of mitosis. The zinc that in

SUBMITTER: Nimmanon T 

PROVIDER: S-EPMC7904737 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature