Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner.

ABSTRACT: Increased reactive oxygen species levels in the mitochondrial matrix can induce Parkin-dependent mitophagy, which selectively degrades dysfunctional mitochondria via the autolysosome pathway. Phosphorylated mitofusin-2 (MFN2), a receptor of parkin RBR E3 ubiquitin-protein ligase (Parkin), interacts with Parkin to promote the ubiquitination of mitochondrial proteins; meanwhile, the mitophagy receptors Optineurin (OPTN) and nuclear dot protein 52 (NDP52) are recruited to damaged mitochondria to promote mitophagy. However, previous studies have not investigated changes in the levels of OPTN, MFN2, and NDP52 during Parkin-mediated mitophagy. Here, we show that mild and sustained hydrogen peroxide (H₂O₂) stimulation induces Parkin-dependent mitophagy accompanied by downreg

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7904769 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature