RNA editing of the 5-HT2C receptor in the central nucleus of the amygdala is involved in resilience behavior.

ABSTRACT: Post-traumatic-stress-disorder (PTSD) is a stress-related condition that may develop after exposure to a severe trauma-event. One of the core brain areas that is considered to be a key regulatory region of PTSD is the amygdala. Specifically, the central amygdala (CeA) is involved in emotion processing and associative fear learning memory, two main circuits involved in PTSD. Long term dysregulation of trauma-related emotional processing may be caused by neuroadaptations that affect gene expression. The adenosine-(A) to-inosine (I) RNA editing machinery is a post-transcriptional process that converts a genomic encoded A to I and is critical for normal brain function and development. Such editing has the potential to increase the transcriptome diversity, and disruption of this process has bee

SUBMITTER: Warhaftig G 

PROVIDER: S-EPMC7904784 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature