Effects of the antibiotic rifaximin on cortical functional connectivity are mediated through insular cortex.

ABSTRACT: It is well-known that antibiotics affect commensal gut bacteria; however, only recently evidence accumulated that gut microbiota (GM) can influence the central nervous system functions. Preclinical animal studies have repeatedly highlighted the effects of antibiotics on brain activity; however, translational studies in humans are still missing. Here, we present a randomized, double-blind, placebo-controlled study investigating the effects of 7 days intake of Rifaximin (non-absorbable antibiotic) on functional brain connectivity (fc) using magnetoencephalography. Sixteen healthy volunteers were tested before and after the treatment, during resting state (rs), and during a social stressor paradigm (Cyberball game-CBG), designed to elicit feelings of exclusion. Results confirm the hypothesis

SUBMITTER: Sometti D 

PROVIDER: S-EPMC7904800 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature