Revealing the role of the human blood plasma proteome in obesity using genetic drivers.

ABSTRACT: Blood circulating proteins are confounded readouts of the biological processes that occur in different tissues and organs. Many proteins have been linked to complex disorders and are also under substantial genetic control. Here, we investigate the associations between over 1000 blood circulating proteins and body mass index (BMI) in three studies including over 4600 participants. We show that BMI is associated with widespread changes in the plasma proteome. We observe 152 replicated protein associations with BMI. 24 proteins also associate with a genome-wide polygenic score (GPS) for BMI. These proteins are involved in lipid metabolism and inflammatory pathways impacting clinically relevant pathways of adiposity. Mendelian randomization suggests a bi-directional causal relationship of BMI

SUBMITTER: Zaghlool SB 

PROVIDER: S-EPMC7904950 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature