Angiogenin maintains gut microbe homeostasis by balancing α-Proteobacteria and Lachnospiraceae.

ABSTRACT:

Objective

Antimicrobial peptides (AMPs) play essential roles in maintaining gut health and are associated with IBD. This study is to elucidate the effect of angiogenin (ANG), an intestine-secreted AMP, on gut microbiota and its relevance with IBD.

Design

The effect of ANG on microbiota and its contribution to colitis were evaluated in different colitis models with co-housing and faecal microbiota transplantation. ANG-regulated bacteria were determined by 16S rDNA sequencing and their functions in colitis were analysed by bacterial colonisation. The species-specific antimicrobial activity of ANG and its underlying mechanism were further investigated with microbiological and biochemical methods. ANG level and the key bacteria were characterised in IBD faecal samples.

Result

SUBMITTER: Sun D 

PROVIDER: S-EPMC7904960 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature