Mutant p53 Gain-of-Function: Role in Cancer Development, Progression, and Therapeutic Approaches.

ABSTRACT: Frequent p53 mutations (mutp53) not only abolish tumor suppressor capacities but confer various gain-of-function (GOF) activities that impacts molecules and pathways now regarded as central for tumor development and progression. Although the complete impact of GOF is still far from being fully understood, the effects on proliferation, migration, metabolic reprogramming, and immune evasion, among others, certainly constitute major driving forces for human tumors harboring them. In this review we discuss major molecular mechanisms driven by mutp53 GOF. We present novel mechanistic insights on their effects over key functional molecules and processes involved in cancer. We analyze new mechanistic insights impacting processes such as immune system evasion, metabolic reprogramming, and stemness

SUBMITTER: Alvarado-Ortiz E 

PROVIDER: S-EPMC7905058 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature