Genetic Background Shapes Phenotypic Response to Diet for Adiposity in the Collaborative Cross.

ABSTRACT: Defined as chronic excessive accumulation of adiposity, obesity results from long-term imbalance between energy intake and expenditure. The mechanisms behind how caloric imbalance occurs are complex and influenced by numerous biological and environmental factors, especially genetics, and diet. Population-based diet recommendations have had limited success partly due to the wide variation in physiological responses across individuals when they consume the same diet. Thus, it is necessary to broaden our understanding of how individual genetics and diet interact relative to the development of obesity for improving weight loss treatment. To determine how consumption of diets with different macronutrient composition alter adiposity and other obesity-related traits in a genetically diverse popul

SUBMITTER: Yam P 

PROVIDER: S-EPMC7905354 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature