Transcriptomic data showing differentially expressed genes between Notch3 and Notch4 deleted mice.

ABSTRACT: The Notch signaling pathway is an important conserved pathway for normal homeostasis during development. However, targeted deletion of Notch4 (Notch4^d1 ) or Notch3 (Notch3^d1 ) in mice is not lethal. In fact, both Notch4^d1 and Notch3^d1 mice develop normally and are fertile. Here we present RNA seq analysis of differential gene expression in the kidneys of Notch4^d1 mice versus the Notch3 ^d1 mice, all on FVB background. Kidneys were collected from Notch4^d1 and Notch3 ^d1 littermates at 3 months of age. RNA sequencing was carried out. The raw data were analyzed for differential gene expression using a negative binomial generalized linear m

SUBMITTER: Sharma M 

PROVIDER: S-EPMC7905437 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature